Attenuating the mortality risk of socioeconomic deprivation in type 2 diabetes: Minimum and compensatory physical activity estimates
Main finding · All-cause mortalityResult — go to the resultHazard ratio 0.423 95% CI 0.286–0.625Authors' conclusion
Achievable MVPA levels may attenuate deprivation-related excess mortality in T2DM.
Study context
- Population
- UK Biobank participants with prevalent T2D and valid wrist-worn accelerometer data
- Participants
- 1,793 participants
- Exposure
- Combined Townsend Deprivation Index (TDI) and moderate-to-vigorous physical activity (MVPA) categories; MVPA dose–response
- Outcome
- All-cause mortality
Methodological detailsUK Biobank, wrist-worn accelerometer, multivariable Cox models, restricted cubic splines, Kneedle-derived threshold detection, compensation-point estimation
- UK Biobank
- Wrist-worn accelerometer
- Multivariable Cox models
- Restricted cubic splines
- Kneedle-derived threshold detection
- Compensation-point estimation
Main finding
As reported in the abstract
Hazard ratio
0.423
95% CI 0.286–0.625
Low TDI, MVPA ≥ 150 min/weekvs High TDI, MVPA < 150 min/week
HR 0.423 (95% CI 0.286–0.625)
Observational data: associations, not effects.
Further findings
MVPA–mortality nonlinear inverse association: thresholds
min/week
- Overall elbow
- 72
- Overall plateau
- 131
- Low TDI elbow
- 68
- Low TDI plateau
- 126
- High TDI elbow
- 76
- High TDI plateau
- 134
Compensation point for high-deprivation individuals
- Compensation point, high deprivation
- 31 min/week
Original publication
Attenuating the mortality risk of socioeconomic deprivation in type 2 diabetes: Minimum and compensatory physical activity estimates. Diabetes Res Clin Pract. Published 4 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →