Association of Post‐Oral Glucose Tolerance Test Hypoglycaemia With Clinical Features, Incident Diabetes and Mortality in the Di@bet.es Cohort
Authors' conclusion
Post-OGTT hypoglycaemia is more frequent in smokers, younger individuals, and those with a favourable metabolic profile. Post-OGTT hypoglycaemia acts as a marker of protection for incident diabetes and mortality.
Study context
- Population
- Adults without known diabetes who underwent a 75-g OGTT in the Di@bet.es Study; median age 49 years, 1680 women
- Participants
- 2,924 adults
- Exposure
- Post-OGTT hypoglycaemia vs other 120-min glucose categories
- Post-OGTT hypoglycaemian = 327
- Outcome
- Incidence of diabetes and mortality
- Follow-up
- Median 7.5 years (diabetes) and 14.5 years (mortality)
Main finding
As reported in the abstract
Incident diabetes and mortality
- Post-OGTT hypoglycaemia had the lowest incidence of diabetes and mortality; associations attenuated after adjusting for confounders (age, sex, BMI, physical activity) and vs the normal result group
Observational data: associations, not effects.
Further findings
- Prevalence of post-OGTT hypoglycaemia
- 11.1% · 327
Clinical features and OGTT glucose/insulin
- Post-OGTT hypoglycaemia: younger, leaner, less insulin resistant and more often active smokers
- Lowest glucose at 0, 30 and 120 min and lowest insulin at 0 and 120 min, but tended to have the highest insulin at 30 min
Original publication
Association of Post‐Oral Glucose Tolerance Test Hypoglycaemia With Clinical Features, Incident Diabetes and Mortality in the Di@bet.es Cohort. Diabetes Obes Metab. Published 4 June 2026. doi:10.
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