Are associations between physical activity and bone mineral density in adults sex- and age-dependent? An analysis of the UK Biobank study
Authors' conclusion
These results suggest that associations between PA and bone health at clinically-relevant sites are weaker in older than younger women.
Study context
- Population
- Middle-aged and older adults in the UK Biobank with complete physical activity (PA), bone and covariate data; 52% women52% women
- Participants
- 15,133 participants
- Exposure
- Accelerometer-measured PA and sedentary time vs LS and FN BMD, by sex and age
- Outcome
- Associations between PA (overall, sedentary, light, moderate-to-vigorous) and LS and FN BMD (DXA), with sex and age interactions
Methodological detailspopulation-based, UK Biobank, wrist-worn accelerometry, linear regression with sex and age interactions
- Population-based
- UK Biobank
- Wrist-worn accelerometry
- Linear regression with sex and age interactions
Main finding
As reported in the abstract
LS BMD
In women, associations weaker in older individuals: regression coefficients at ≥70 yr ≈50% lower than at 45-54 yr
age-by-PA interactions P < .01 in all models
Observational data: associations, not effects.
Further findings
FN BMD
- Similar associations in basic but not full models for FN BMD
- Greater light PA and sedentary time associated with higher and lower FN BMD, respectively, in both sexes
Sedentary time and LS BMD
- Greater sedentary time associated with lower LS BMD in men only
Original publication
Are associations between physical activity and bone mineral density in adults sex- and age-dependent? An analysis of the UK Biobank study. J Bone Miner Res. Published 29 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →