Decline in muscle strength and physical function after fracture in men – the prospective STRAMBO study
Authors' conclusion
Overall, in older men, fractures were associated with greater loss of muscle strength and physical function vs. normal ageing. This accelerated decline was also found in the anatomical regions remote from the fracture site.
Study context
- Population
- Men aged 60–87; grip strength and clinical tests (chair stands, balance) every 4 years for 12 years
- Participants
- 823 men
- Exposure
- Men with incident fracture vs men without fracture
- Fracturen = 155
- Outcome
- Grip strength decline and physical function deterioration
Main finding
As reported in the abstract
- Incident deterioration on five chair-stand test
- OR 2.45; P < 0.001
- Incident inability to stand 10s with closed eyes
- OR 4.80; P < 0.01
- Deterioration on tandem walk forwards
- OR 2.04; P < 0.01
- Deterioration on tandem walk backwards
- OR 2.25; P < 0.005
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | P value |
|---|---|---|
| Grip strength decrease, non-upper limb fracturesGreater decrease with non-upper limb fractures | 32% | P < 0.05 |
| Decline in chair stands, non-lower limb fracturesNon-lower limb fractures | OR 2.73 | P < 0.001 |
| Tandem walk forwards decline, clinical fractures >1 year before next visitClinical fractures >1 year before next visit | OR 2.98 | P < 0.005 |
Original publication
Decline in muscle strength and physical function after fracture in men – the prospective STRAMBO study. J Bone Miner Res. Published 28 January 2024. doi:10.
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