Agreement between routinely used immunoassays for thyroid function testing in non‐pregnant and pregnant adults
Authors' conclusion
Results of thyroid function tests obtained with different immunoassays were not interchangeable when evaluated among pregnant and non-pregnant adults. The distinct differences are relevant for clinical decision making and emphasize the necessity of clinical laboratory information when different assays are used for diagnosis and monitoring of patients with thyroid disease.
Study context
- Population
- Blood donors (non-pregnant adults) and pregnant women with no known thyroid disease, North Denmark Region192 donors, 86 pregnant
- Exposure
- Agreement of Thyroid-stimulating Hormone (TSH) immunoassays: Alinity vs Cobas vs Atellica
- Outcome
- TSH in non-pregnant adults
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
Median, mIU/L
| Outcome | Alinity | Cobas |
|---|---|---|
| TSH in pregnant women | 1.90 (95% CI 1.37–2.82) | 2.33 (95% CI 1.69–3.62) |
TSH in pregnant women
- Trend towards higher median TSH with Cobas than with Alinity
Original publication
Agreement between routinely used immunoassays for thyroid function testing in non‐pregnant and pregnant adults. Clin Endocrinol (Oxf). Published 17 April 2024. doi:10.
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