Aggressive Subtypes of Papillary Thyroid Carcinoma Smaller Than 1 cm
Authors' conclusion
Aggressive subtypes of small PTC tumors smaller than or equal to 1 cm exhibited more extrathyroidal extension and neck node metastasis. This study suggests that surgeons should consider the aggressive subtypes as important factors when deciding the range of surgery in PTCs smaller than 1 cm.
Study context
- Population
- Patients with PTC ≤1 cm who underwent thyroidectomy, January 2009–December 2016
- Participants
- 11,570 patients
- Exposure
- Aggressive vs nonaggressive PTC subtypes
- Aggressive PTC subtypesn = 177
- Outcome
- Extrathyroidal extension
Methodological detailspropensity score matching
- Propensity score matching
Main finding
As reported in the abstract
95% CI 0.41–0.80; P < 0.001
Observational data: associations, not effects.
Further findings
Recurrence
| Outcome | Aggressive PTC subtypes | Nonaggressive PTC subtypes | Estimate | P value |
|---|---|---|---|---|
| Metastatic central neck lymph nodes | 3.06 ± 3.67 | 1.22 ± 2.14 | (95% CI 1.42–2.26) | P < 0.001 |
| Metastatic lateral neck lymph nodes | 3.81 ± 5.39 | 2.85 ± 3.79 | (95% CI 2.9–5.90) | P < 0.001 |
Original publication
Aggressive Subtypes of Papillary Thyroid Carcinoma Smaller Than 1 cm. J Clin Endocrinol Metab. Published 21 December 2022. doi:10.
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