Age‐ and sex‐dependent lipid trajectories in children and adolescents with type 1 diabetes—A Danish nationwide registry‐based study
Authors' conclusion
TC, LDL-C, HDL-C and triglycerides vary with age and sex in children and adolescents with type 1 diabetes. In addition, a high proportion of adolescents, particularly girls, have LDL-C levels above the intervention threshold. The results call for more research on age- and sex-specific levels of LDL-C that should lead to intervention to prevent future cardiovascular events.
Study context
- Population
- Children and adolescents <19 years with T1D and ≥2 lipid measurements, DanDiabKids, 2005–20198,563 lipid measurements
- Participants
- 1,188 vs 1,288
- Exposure
- Girls vs boys; lipid trajectories over age
- Girlsn = 1,188
- Boysn = 1,288
- Outcome
- Lipid trajectories (TC, LDL-C, HDL-C, TG) by age and sex
Methodological detailslinear mixed effects models, adjusted for potential confounders, sex differences examined as interactions
- Linear mixed effects models
- Adjusted for potential confounders
- Sex differences examined as interactions
Main finding
As reported in the abstract
- Girls: Total cholesterol (TC), LDL-C and TG increased across all ages; HDL-C declined slightly
- Boys: TC, LDL-C and HDL-C decreased from around 12 years; TG increased over the entire age scale
Observational data: associations, not effects.
Further findings
Effect of HbA1c and BMI on LDL-C
- Higher HbA1c and BMI z-scores associated with higher LDL-C
LDL-C above ISPAD limit for intervention
- Individuals with LDL-C above the limit for intervention, depending on age and sex
- 19%-42%
Diabetes duration at last visit
- Median (Q1-Q3) diabetes duration
- 6.4 years (4-9.6 years)
Original publication
Age‐ and sex‐dependent lipid trajectories in children and adolescents with type 1 diabetes—A Danish nationwide registry‐based study. Diabet Med. Published 22 April 2025. doi:10.
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