Adolescent Body Mass Index, Weight Trajectories to Adulthood, and Osteoporosis Risk
Authors' conclusion
In this cohort study, BMI at a young age and its trajectory to adulthood were significantly associated with risk for osteoporosis in adult life.
Study context
- Population
- Israeli-born adolescents aged 16 to 19 years evaluated for military service, 1967 to 2019
- Participants
- 1,083,491 adolescents19,400,208 person-years
- Exposure
- Adolescent body mass index (BMI) categories vs normal BMI
- Outcome
- Osteoporosis diagnosis recorded in the Maccabi Healthcare Services osteoporosis registry
- Follow-up
- Until 2022
Methodological detailspopulation-based, Cox proportional hazard models
- Population-based
- Cox proportional hazard models
Main finding
As reported in the abstract
Osteoporosis, by adolescent BMI
- aHR range in women (vs normal BMI)
- 1.88 (95% CI, 1.74-2.04) to 0.83 (95% CI, 0.77-0.89)
- aHR range in men (vs normal BMI)
- 1.82 (95% CI, 1.64-2.01) to 1.04 (95% CI, 0.93-1.16)
Observational data: associations, not effects.
Further findings
Osteoporosis by adolescence-to-adulthood weight trajectory
- Highest risk in individuals who remained underweight from adolescence into adulthood
- Adult BMI available for 74%
Original publication
Adolescent Body Mass Index, Weight Trajectories to Adulthood, and Osteoporosis Risk. JAMA Netw Open. Published 1 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →