Bone Microarchitecture Evaluated by HR-PQCT in Chinese Adolescent and Pediatric Patients With X-Linked Hypophosphatemia
Authors' conclusion
The bone microarchitecture of adolescent and pediatric patients with XLH had deteriorated, and ALP-Z was negatively correlated with the skeletal quality of adolescent and pediatric patients with XLH, especially in the cortical bone. HR-pQCT parameters can be estimated using clinical characteristics and biochemical indicators, which may assist physicians to monitor the disease progression in areas without HR-pQCT access.
Study context
- Population
- Chinese adolescent and pediatric patients with X-linked hypophosphatemia (XLH)
- Exposure
- XLH vs sex- and age-matched controls
- XLHn = 106
- Outcome
- HR-pQCT bone geometry, density, microarchitecture and stiffness at distal radius and tibia
Methodological detailssex- and age-matched controls, high-resolution peripheral quantitative computed tomography (HR-pQCT)
- Sex- and age-matched controls
- HR-pQCT
Main finding
As reported in the abstract
- XLH vs controls: significantly higher trabecular area (Tb.Ar), lower total vBMD, lower cortical vBMD (Ct.vBMD) and lower stiffness at both distal radius and tibia, adjusted for height and weight
- ALP Z score (ALP-Z) negatively correlated with Ct.vBMD and cortical thickness at distal radius and Ct.vBMD at distal tibia; positively correlated with cortical porosity at distal tibia
Observational data: associations, not effects.
Further findings
- Online calculator developed to estimate Tb.Ar, Ct.vBMD and stiffness of distal tibia from clinical characteristics and biochemical indicators
Original publication
Bone Microarchitecture Evaluated by HR-PQCT in Chinese Adolescent and Pediatric Patients With X-Linked Hypophosphatemia. J Clin Endocrinol Metab. Published 14 November 2024. doi:10.
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