First fracture in rheumatoid arthritis: analysis by fracture site, gender, age, and comorbidities
Main finding · First fracture, IR per 1000 PY (2000–2010)Result — go to the resultIncidence rate ratio 1.32 CI 1.10–1.60Authors' conclusion
After age, gender, and comorbidity adjustment, RA is associated with a 32% higher incidence of first fracture, increased MOF, and a fracture incidence that is already increased before a first recorded RA diagnosis.
Study context
- Population
- Rheumatoid arthritis (RA) patients and matched hospitalised controls, West Australian Rheumatic Disease Epidemiological Registry (WARDER), 1980–2015
- Exposure
- RA vs matched hospitalised controls free of rheumatic disease
- Outcome
- Incidence of first fracture (IR per 1000 PY)
Methodological detailslongitudinal, routinely collected administrative data, matched on age, gender and comorbidities (Charlson Comorbidity Index)
- Longitudinal
- Routinely collected administrative data
- Matched on age, gender and comorbidities (Charlson Comorbidity Index)
Main finding
First fracture, IR per 1000 PY (2000–2010)
Incidence rate ratio
1.32
CI 1.10–1.60
By group
RA
18.3
Incidence rates (IR) · CI 15.7–21.2 · per 1000 person years (PY)
RAvs Controls
IRR 1.32 (CI 1.10–1.60)
As reported in the abstract
Observational data: associations, not effects.
Further findings
IR, per 1000 PY
| Outcome | RA | Estimate | |
|---|---|---|---|
| Upper limb fracture, IR per 1000 PY | 5.56 (95% CI 4.18–7.26) | IRR 1.18 (95% CI 0.84–1.65) | |
| Lower limb fracture, IR per 1000 PY | 10.60 (95% CI 8.66–12.87) | IRR 1.44 (95% CI 1.19–1.86) | |
| Axial fracture, IR per 1000 PYCI as printed does not contain the point estimate | 2.47 (95% CI 2.58–3.68) | IRR 1.01 (95% CI 0.61–1.63) | |
| First fracture before first RA hospital record · 6 years before first RA hospital record | RR 1.58 (CI 1.05–2.39) | ||
| 0.512Ratio (log scale) |
Original publication
First fracture in rheumatoid arthritis: analysis by fracture site, gender, age, and comorbidities. Osteoporos Int. Published 12 November 2024. doi:10.
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