A comprehensive meta-analysis of risk factors associated with osteosarcopenic obesity: a closer look at gender, lifestyle and comorbidities
Authors' conclusion
Our study underscored the substantial role of female gender, physical inactivity, and hypertension in the development of OSO, whilst suggesting a strong link between OSO and frailty.
Study context
- Population
- Studies of osteosarcopenic obesity (OSO) risk factors from PubMed, Scopus and Cochrane, to June 2023
- Participants
- 178,546 participants21 studies
- Outcome
- Association of risk factors (age, gender, lifestyle factors, common comorbidities) with OSO, pooled odds ratios (ORs)
Methodological detailsrandom-effects model
- Random-effects model
Pooled result
As reported in the abstract
Risk factors associated with OSO (pooled OR)
- Female gender, OR
- 1.756 (95% CI 1.081 to 2.858)
- Physical inactivity, OR
- 1.562 (95% CI 1.127-2.165)
- Hypertension, OR
- 1.482 (95% CI 1.207-1.821)
- Smoking, OR (95% CI 0.672-1.084); no significant association
- 0.854
- Alcohol consumption, OR (95% CI 0.372-1.328); no significant association
- 0.703
- Dyslipidemia, OR (95% CI 0.982-1.841); no significant association
- 1.345
- Frailty, OR
- 6.091 (95% CI 3.576-10.375)
Original publication
A comprehensive meta-analysis of risk factors associated with osteosarcopenic obesity: a closer look at gender, lifestyle and comorbidities. Osteoporos Int. Published 15 January 2024. doi:10.
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