Association between fatty liver index and controlled attenuation parameters as markers of metabolic dysfunction-associated fatty liver disease and bone mineral density: observational and two-sample Mendelian randomization studies
Authors' conclusion
No causal effect of MAFLD and hepatic steatosis on BMD was observed in this study, while some metabolic factors were correlated with BMD. This has important implications for understanding the relationship between fatty liver disease and BMD, which may help direct the clinical management of MAFLD patients with osteoporosis.
Study context
- Population
- UK Biobank and National Health and Nutrition Examination Survey (NHANES) participants
- Exposure
- MAFLD and hepatic steatosis vs bone mineral density (BMD)
- Outcome
- Association of MAFLD and steatosis with BMD
Methodological detailsUK Biobank and NHANES datasets, genome-wide association analysis
- UK Biobank and NHANES datasets
- Genome-wide association analysis
Main finding
As reported in the abstract
- Adjusted for demographics and BMI, MAFLD significantly associated with reduced heel BMD; association disappeared after adjusting for additional metabolic factors
- MAFLD not associated with total body, femur neck and lumbar BMD (NHANES)
- MRI-measured steatosis not significantly associated with reduced total body, femur neck and lumbar BMD in multivariate analysis
- Two-sample Mendelian randomization (TSMR): MAFLD and hepatic steatosis not associated with BMD
Observational data: associations, not effects.
Further findings
MAFLD-related comorbid factors and BMD (TSMR)
- Overweight and T2D showed a causal relationship with increased BMD; waist circumference and hyperlipidemia had the opposite effect
Original publication
Association between fatty liver index and controlled attenuation parameters as markers of metabolic dysfunction-associated fatty liver disease and bone mineral density: observational and two-sample Mendelian randomization studies. Osteoporos Int. Published 15 January 2024. doi:10.
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