Heel quantitative ultrasound (QUS) predicts incident fractures independently of trabecular bone score (TBS), bone mineral density (BMD), and FRAX: the OsteoLaus Study
Authors' conclusion
Heel-QUS predicts fracture independently of FRAX, BMD, and TBS.
Study context
- Population
- Postmenopausal women from the OsteoLaus cohort followed up for 7 years200 major osteoporotic fractures (MOF) recorded
- Participants
- 1,345 women
- Exposure
- Heel-QUS parameters (stiffness index (SI), broadband ultrasound attenuation (BUA), speed of sound (SOS)) per SD decrease, adjusted for FRAX-CRF, treatment, BMD and TBS
- Outcome
- Incident major osteoporotic fractures (MOF)
Methodological detailspopulation-based cohort (OsteoLaus), assessments every 2.5 years, multivariable regression
- Population-based cohort (OsteoLaus)
- Assessments every 2.5 years
- Multivariable regression
Main finding
As reported in the abstract
MOF risk per 1-SD decrease in heel-QUS parameter, adjusted for FRAX-CRF, treatment, BMD and TBS · mean follow-up 6.7 years
SI, OR
1.43 (1.18-1.75) (95% CI)
BUA, OR
1.19 (0.99-1.43) (95% CI)
SOS, OR
1.52 (1.26-1.84) (95% CI)
Observational data: associations, not effects.
Further findings
Correlation of TBS with heel-QUS parameters
- TBS with SOS
- 0.409
- TBS with SI
- 0.472
Change of QUS parameters over 2.5 years and incident MOF
- No association between change of QUS parameters in 2.5 years and incident MOF
Original publication
Heel quantitative ultrasound (QUS) predicts incident fractures independently of trabecular bone score (TBS), bone mineral density (BMD), and FRAX: the OsteoLaus Study. Osteoporos Int. Published 8 May 2023. doi:10.
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