Is there an association between birth characteristics and fractures in young adults? The HUNT Study, Norway
Authors' conclusion
Birth weight, gestational age, or birth weight for gestational age was not associated with an increased risk of fractures of the wrist, humerus, hip, and spine in young adults.
Study context
- Population
- Young adults (19–54 years) in the 3rd survey of the HUNT Study (2006–2008), Norwayaged 19–54 years
- Participants
- 11,099 adults
- Exposure
- Birth characteristics and fracture risk
- Outcome
- Fracture of wrist, humerus, hip or spine
- Follow-up
- Median 14.0 years
Methodological detailspopulation-based, registry linkage (Medical Birth Registry of Norway and hospital records), Cox regression adjusted for birth year, sex, maternal age and maternal morbidity
- Population-based
- Registry linkage (Medical Birth Registry of Norway and hospital records)
- Cox regression adjusted for birth year, sex, maternal age and maternal morbidity
Main finding
As reported in the abstract
Hazard ratio (95% CI)
Birth weight < 2.5 kgvs Birth weight 3.5 - 3.9 kg
0.43(0.15–1.24)
Small for gestational agevs 10 - 90th percentile
1.04(0.74–1.46)
Pretermvs Term births
0.63(0.33–1.23)
- Mean age at first fracture, years (SD 7.4)
- 41.4
Observational data: associations, not effects.
Further findings
Fractures with follow-up from 1988 (secondary analysis)
- 539 fractures; similar results as the main analysis
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Is there an association between birth characteristics and fractures in young adults? The HUNT Study, Norway. Osteoporos Int. Published 8 January 2025. doi:10.
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