Burden of accumulating fragility fractures on health service usage and costs among post-menopausal women
Authors' conclusion
An increasing number of fragility fractures is associated with the elevated societal costs and the burden on healthcare services even after adjustment for age, comorbidities, education level, and BMI.
Study context
- Population
- Finnish post-menopausal women born between 1932 and 1945 (OSTPRE and Kuopio Fall Prevention Study (KFPS) cohorts)over 533,570 person-years
- Participants
- 16,726 women
- Exposure
- Women with increasing numbers of fragility fractures vs women without fractures
- Outcome
- Mortality, admissions to long-term care, inpatient care days and healthcare costs
- Follow-up
- Median 33.7 years
Methodological detailspooled data from OSTPRE and KFPS cohorts, linked healthcare and social welfare registers, generalized linear mixed models
- Pooled data from OSTPRE and KFPS cohorts
- Linked healthcare and social welfare registers
- Generalized linear mixed models
Main finding
As reported in the abstract
≥3 fractures vs Without fracturesIncidence rate ratio (95% CI)
Mortality rate
2.2(2.0–2.4)
- Times higher annual healthcare costs
- 1.4 (95% CI 1.3–1.5)
Observational data: associations, not effects.
Original publication
Burden of accumulating fragility fractures on health service usage and costs among post-menopausal women. Osteoporos Int. Published 16 December 2025. doi:10.
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