Acute Exercise Increases GDF15 and Unfolded Protein Response/Integrated Stress Response in Muscle in Type 2 Diabetes
Authors' conclusion
In conclusion, exercise-induced regulation of GDF15 and key markers of UPR/ISR are not compromised in patients with T2D compared with weight-matched controls.
Study context
- Population
- Men with T2D and age- and weight-matched overweight/obese glucose-tolerant men; blood and muscle biopsies before, immediately after and 3 hours into recovery
- Participants
- 13 vs 14
- Comparison
- Male patients with T2D vs age- and weight-matched overweight/obese glucose-tolerant men
- T2Dn = 13
- Controlsn = 14reference
- Outcome
- Exercise-induced regulation of GDF15 (serum and muscle) and UPR/ISR markers in skeletal muscle
- Follow-up
- Before, immediately after, and 3 hours into recovery
Methodological detailsacute exercise at 70% of VO2max for 1 hour, age- and weight-matched controls
- Acute exercise at 70% of VO2max for 1 hour
- Age- and weight-matched controls
Main finding
As reported in the abstract
- Acute exercise increased muscle gene expression and serum GDF15 in both groups
- In recovery, muscle GDF15 expression decreased toward baseline, whereas serum GDF15 remained elevated
- In both groups, exercise increased unfolded protein response (UPR)/integrated stress response (ISR) markers ATF4, CHOP, EIF2K3 (PERK) and PPP1R15A (GADD34); only CHOP remained elevated 3 hours into recovery
- XBP1-U, XBP1-S and EDEM1 increased with exercise and 3 hours into recovery in both groups
- eIF2α-Ser51 phosphorylation increased immediately after exercise in controls, but decreased 3 hours into recovery in both groups
Original publication
Acute Exercise Increases GDF15 and Unfolded Protein Response/Integrated Stress Response in Muscle in Type 2 Diabetes. J Clin Endocrinol Metab. Published 18 January 2024. doi:10.
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