Active Surveillance of Differentiated Thyroid Cancer Metastatic Cervical Lymph Nodes: A Retrospective Single-Center Cohort Study
Authors' conclusion
We observed that most small metastatic cervical LNs remained stable and were safely managed with AS.
Study context
- Population
- Differentiated thyroid cancer (DTC) patients with biopsy-proven metastatic cervical lymph nodes (LNs) ≤2.0 cm on active surveillance (AS) for ≥6 months, Brazil; aggressive histology or lesions near/invading local structures excluded; 77.5% female, 97.5% PTC, mean age 47.0 (SD 15.8) yearsanalysed
- Participants
- 40 patients
- Outcome
- Disease progression (enlargement ≥3 mm in any diameter or a new cervical metastasis)
Methodological detailssingle-center, tertiary care, university-based institution
- Single-center
- Tertiary care, university-based institution
Main finding
As reported in the abstract
Disease progression · median AS follow-up 27.5 (IQR, 16.5-47.3) months
AS
35%
14 events
- Enlargement ≥3 mm
- 7 (17.5%)
- New cervical metastasis
- 7 (17.5%)
- Cervical progression-free survival
- 51.0 (CI, 47.0-55.0) months
Observational data: associations, not effects.
Further findings
Factors associated with disease progression
- No demographic, oncological or biochemical factors were associated with disease progression
Management after progression
- Of 14 with progression, referred for surgery
- 8
- Of 6 remaining on AS despite progression, no further progression (range 6-40 months)
- 5
Safety
- Permanent surgical complications
- 0
Original publication
Active Surveillance of Differentiated Thyroid Cancer Metastatic Cervical Lymph Nodes: A Retrospective Single-Center Cohort Study. Thyroid. Published 15 February 2023. doi:10.
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