17β‐hydroxysteroid dehydrogenase type 2 activity, expression and cellular localization in abdominal adipose tissues from women
Authors' conclusion
17β-HSD2 converts E2 to E1 in OM and SC adipose tissues of women. The activity of this enzyme decreases with increasing adiposity.
Study context
- Population
- Women; Omental (OM) and subcutaneous (SC) adipose tissues
- Participants
- 29 women
- Comparison
- OM vs SC adipose tissue
- Outcome
- Conversion of E2 into E1 (rates of 14 C-E1 formation from 14 C-E2) in OM and SC adipose tissue homogenates
Main finding
As reported in the abstract
Rate of 14 C-E1 formation from 14 C-E2
- Significant 14 C-E1 formation from 14 C-E2 in OM and SC tissue homogenates
- OM vs SC: P < 0.0001
Further findings
| Outcome | P value |
|---|---|
| 17β-HSD2 mRNA expression (n = 14)Significantly higher in OM | P = 0.03 |
Inhibition of 14 C-E2 to 14 C-E1 conversion by EM-919 (n = 6)
- Significantly inhibited by EM-919 in OM
- P < 0.05
- Significantly inhibited by EM-919 in SC
- P < 0.05
Cellular localization of 17β-HSD2
- 17β-HSD2 localized in the vasculature of OM and SC tissues
Associations of OM 17β-HSD2 activity with adiposity
- Significant negative associations between OM 17β-HSD2 activity and BMI, WC, lean body mass and SC adipose tissue areas
Original publication
17β‐hydroxysteroid dehydrogenase type 2 activity, expression and cellular localization in abdominal adipose tissues from women. Clin Endocrinol (Oxf). Published 31 October 2022. doi:10.
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