Regional Variation in Hormonal and Metabolic Parameters of White and Black Women With Polycystic Ovary Syndrome (PCOS) in the United States
Authors' conclusion
Alabama women with PCOS, regardless of Black or White race, were more likely hirsute with metabolic dysfunction, whereas California women with PCOS were more likely to demonstrate hyperandrogenemia, highlighting potential environmental impacts on PCOS.
Study context
- Population
- Women with PCOS by National Institutes of Health Criteria, 1987–2010, tertiary-care specialty clinics in Alabama and California
- Participants
- 1,610 women
- Exposure
- Women with PCOS in Alabama vs California
- Outcome
- Hormonal and metabolic parameters of women with PCOS in 2 environments
Methodological detailstertiary-care specialty clinics, 2 sites (Alabama and California)
- Tertiary-care specialty clinics
- 2 sites (Alabama and California)
Main finding
As reported in the abstract
Hormonal and metabolic parameters, Alabama vs California, adjusted for age and BMI
Alabama vs CaliforniaAdjusted odds ratio (95% CI)P value
Hirsutism; more likely in Alabama
1.8(1.4–2.4)
P < 0.001Hyperandrogenemia by free testosterone; more likely in California
0.14(0.11–0.18)
P < 0.001Hyperandrogenemia by total testosterone; more likely in California
0.41(0.33–0.51)
- Homeostatic model assessment for insulin resistance (HOMA-IR); elevated in Alabama
- adjusted beta coefficient 3.6 (95% CI 1.61–5.5); P < 0.001
Observational data: associations, not effects.
Further findings
White women with PCOS
- Results were similar when stratified by White race
Black women with PCOS
- Body mass index (BMI) and waist-hip-ratio (WHR) did not differ between locations, yet differences in androgen profiles and metabolic dysfunction remained
Original publication
Regional Variation in Hormonal and Metabolic Parameters of White and Black Women With PCOS in the United States. J Clin Endocrinol Metab. Published 11 October 2022. doi:10.
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