Reproductive endocrinology

Population-Based vs Health System and Insurer Records: Significant Underdiagnosis of Polycystic Ovary Syndrome (PCOS)

J Clin Endocrinol MetabPublished Systematic review

Authors' conclusion

Our data revealed a substantially lower rate of PCOS in HSIR relative to population-based studies in the United States, the United Kingdom, and South Korea, likely indicating that PCOS is underdiagnosed and/or underreported. Overall, these findings highlight the critical need to improve the awareness of health care practitioners and payers, and likely the public at large, regarding PCOS.

Study context

Population
Studies reporting PCOS prevalence in the general population and in HSIR, from the same populations in 3 countries (United States, UK, South Korea); PubMed and Embase through July 20237 population-based, 11 HSIR-based studies
Participants
7 vs 11
Comparison
PCOS prevalence in population-based studies vs Health System or Insurer Records (HSIR)
  • Population-basedn = 7reference
  • HSIRn = 11
Outcome
Extent of PCOS underdiagnosis: PCOS prevalence in population-based vs HSIR-based studies
Methodological details6583 records identified
  • 6583 records identified

Pooled result

As reported in the abstract

PCOS prevalence
United States, population-based studies
between 4% and 19.6%
United States, HSIR-based studies
0.2% to 5.2%
UK, HSIR-based study
1.34%
UK, population
around 8%
South Korea, 2 population-based studies
4.9% and 7%
South Korea, one HSIR
0.12% to 0.33%
South Korea, another HSIR
4.3%

Further pooled results

Where data were available, PCOS detection in HSIR appeared to improve over time, though still far from the actual population prevalence

Original publication

Population-Based vs Health System and Insurer Records: Significant Underdiagnosis of PCOS. J Clin Endocrinol Metab. Published 21 January 2025. doi:10.1210/clinem/dgaf037

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