Gestational diabetes & diabetes in pregnancy
Women With Higher Glucose Challenge Test (GCT) Levels but NGT Have a Similarly High Risk for Glucose Intolerance Postpartum as Women With Gestational Diabetes Mellitus (GDM)
Main finding · GI in mothersResult — go to the resultAdjusted odds ratio 2.87 CI 1.47–5.60Authors' conclusion
NGT women with GCT greater than or equal to 8.3 mmol/L (≥150 mg/dL) in pregnancy have a similarly high risk for GI 5.7 years postpartum as women with GDM. These women also need postpartum follow-up to prevent GI.
Study context
- Population
- Women from the Belgian Diabetes in Pregnancy study (BEDIP-N) and their offspring, 3 to 7 years postpartumplus 296 children
- Participants
- 334 women
- Exposure
- Abnormal GCT-NGT and GDM vs normal GCT-NGT
- Normal GCT-NGTn = 213reference
- Abnormal GCT-NGTn = 39
- GDMn = 82
- Outcome
- Glucose intolerance (GI) postpartum
- Follow-up
- 5.7 years postpartum
Methodological detailsmulticentre, follow-up of the BEDIP-N prospective observational study
- Multicentre
- Follow-up of the BEDIP-N prospective observational study
Main finding
GI in mothers
Adjusted odds ratio
2.87
CI 1.47–5.60
P = 0.0020
Abnormal GCT-NGTvs Normal GCT-NGT
aOR 2.87 (CI 1.47–5.60); P = 0.0020
As reported in the abstract
Observational data: associations, not effects.
Further findings
GCT cutoff predicting glucose intolerance (GI) (highest Youden index) · 5.7 years postpartum
- GCT cutoff
- ≥8.3 mmol/L (≥150 mg/dL)
β-cell function
- β-cell function decreased over the gestational glucose tolerance groups, with similar β-cell dysfunction in GDM and abnormal GCT-NGT
Offspring metabolic profile · postpartum
- Offspring of women with hyperglycemia less than GDM did not have an increased risk for an adverse metabolic profile
Original publication
Women With Higher GCT Levels but NGT Have a Similarly High Risk for Glucose Intolerance Postpartum as Women With GDM. J Clin Endocrinol Metab. Published 8 May 2025. doi:10.
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