Gestational diabetes & diabetes in pregnancy
Women with gestational diabetes mellitus, controlled for plasma glucose level, exhibit maternal and fetal dyslipidaemia that may warrant treatment
Authors' conclusion
Increased maternal lipoprotein number, but not TG enrichment, in GDM mothers may explain TG enrichment of cord lipoproteins.
Study context
- Population
- Pregnant women with Gestational Diabetes Mellitus (GDM) and healthy pregnant women; fasted maternal blood at 28.6 ± 3.4 (T1) and 36.2 ± 1.0 (T2) weeks, and cord blood
- Exposure
- GDM vs healthy pregnancy
- Outcome
- Maternal and fetal cord plasma and lipoprotein TG concentrations
Main finding
As reported in the abstract
Maternal plasma TG · T1
Observational data: associations, not effects.
Further findings
Maternal plasma apolipoprotein B · T1
Plasma VLDL total protein · T1
Plasma VLDL total cholesterol · T1
Plasma VLDL phospholipid · T1
Plasma glucose
- Plasma glucose did not differ between GDM and healthy women
Maternal plasma apolipoprotein B · T1
- Higher in GDM than healthy
Plasma VLDL total protein · T1
- Higher in GDM than healthy
Plasma VLDL total cholesterol · T1
- Higher in GDM than healthy
Plasma VLDL phospholipid · T1
- Higher in GDM than healthy, and similarly for IDL, suggesting increased lipoprotein particle number
VLDL-TG and IDL-TG enrichment · T1 to T2
- T1 VLDL-TG enrichment higher in healthy; increased over gestation in GDM but decreased in healthy
- IDL-TG enrichment (triglyceride (TG)/total cholesterol (TC)) increased over gestation in GDM and decreased in healthy
Original publication
Women with gestational diabetes mellitus, controlled for plasma glucose level, exhibit maternal and fetal dyslipidaemia that may warrant treatment. Diabetes Res Clin Pract. Published 30 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →