Women Have Greater Endothelin-B Receptor Function and Lower Mitochondrial Capacity Compared to Men With Type 1 Diabetes
Authors' conclusion
Compared to men with uncomplicated T1D, muscle oxidative capacity was lower and ETBR-mediated vasodilation was higher in women with uncomplicated T1D. ETBR-induced vasodilatory capacity was inversely related to skeletal muscle oxidative capacity, suggesting there may be compensatory mechanisms occurring to preserve microvascular blood flow in women with T1D.
Study context
- Population
- Adults with uncomplicated T1D
- Participants
- 10 vs 9
- Comparison
- Women vs men with T1D
- Womenn = 10
- Menn = 9reference
- Outcome
- ETBR-mediated dilation (intradermal microdialysis, BQ-123 + ET-1) and its relation to skeletal muscle oxidative capacity (near-infrared spectroscopy (NIRS))
Main finding
As reported in the abstract
ETBR-mediated vasodilation
- Women vs Men: P = 0.012
Further findings
| Outcome | P value |
|---|---|
| Skeletal muscle oxidative capacitySignificantly lower in women | P = 0.031 |
Correlation of endothelin-B receptor (ETBR)-mediated dilation AUC with skeletal muscle oxidative capacity
- Negative association, r
- −.620; P = .042
Original publication
Women Have Greater Endothelin-B Receptor Function and Lower Mitochondrial Capacity Compared to Men With Type 1 Diabetes. J Clin Endocrinol Metab. Published 3 April 2023. doi:10.
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