Skeletal muscle mitochondrial health in type 1 diabetes: the role of exercise capacity and lifestyle factors
Authors' conclusion
Collectively, our study demonstrates that when matched for age, sex, BMI and V ˙ O 2max , maximal muscle mitochondrial respiration and morphology in people with type 1 diabetes are not impaired. These findings highlight the importance of habitual exercise, optimal glucose management and a healthy BMI in maintaining mitochondrial health in individuals with type 1 diabetes.
Study context
- Population
- Individuals with T1D and healthy controls matched for age, sex, BMI and V ˙ O 2max; vastus lateralis muscle biopsymatched
- Participants
- 17 vs 17
- Comparison
- T1D vs healthy controls
- T1Dn = 17
- Controln = 17reference
- Outcome
- Mitochondrial oxidative phosphorylation capacity
Methodological detailsmatched for age, sex, BMI and V ˙ O 2max, Respiration by high-resolution respirometry; density and morphology by transmission electron microscopy
- Matched for age, sex, BMI and V ˙ O 2max
- Respiration by high-resolution respirometry; density and morphology by transmission electron microscopy
Main finding
As reported in the abstract
P = 0.82
Further findings
Intermyofibrillar mitochondrial density
P = 0.92
Subsarcolemmal mitochondrial density
P = 0.83
| Outcome | T1D | Control | P value |
|---|---|---|---|
| V ˙ O 2max | 40 ± 10 kg-1 min-1 | 41 ± 8 ml kg-1 min-1 | P = 0.51 |
Mitochondrial respiration normalised by density; HbA1c and BMI within T1D
- Respiration normalised by density did not differ between groups
- T1D with higher HbA1c had lower mitochondrial respiration than those with lower HbA1c
- Higher BMI associated with lower mitochondrial densities than lower BMI
Original publication
Skeletal muscle mitochondrial health in type 1 diabetes: the role of exercise capacity and lifestyle factors. Diabetologia. Published 21 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →