Weight variability and cardiovascular outcomes: a systematic review and meta-analysis
Authors' conclusion
In conclusion, body weight variability is associated with increased risk of CV diseases regardless of ethnicity or diabetes status.
Study context
- Population
- Studies of body weight or BMI variability and cardiovascular disease (CVD); PubMed, Web of Science, Cochrane Library
- Participants
- 15,382,537 participants23 studies
- Comparison
- Highest vs lower strata of body weight variability
- Outcome
- Risk of CVD: any cardiovascular (CV) event, composite CV outcome, CV death, stroke, MI
Methodological detailsMOOSE guidelines, random-effects model, 5645 articles screened
- MOOSE guidelines
- Random-effects model
- 5645 articles screened
Pooled result
As reported in the abstract
CVD outcomes, highest strata of body weight variability
Highest weight variabilityEstimate (95% CI)P value
I2 = 97.28%
RR, any CV event 1.27(1.17–1.38)
P < 0.0001I2 = 55.16%
RR, CV death 1.29(1.03–1.60)
P < 0.0001I2 = 97.14%
RR, MI 1.32(1.09–1.59)
P = 0.0037I2 = 0.06%
RR, stroke 1.21(1.19–1.24)
P < 0.0001I2 = 92.41%
RR, compound CVD outcomes 1.36(1.08–1.73)
P = 0.01Further pooled results
BMI variability and per unit SD increase in body weight variability
- Similar relative risks (RRs) observed
Subgroups by diabetes status and ethnicity
- Comparable effects in people with and without diabetes, in White Europeans and Asians
Original publication
Weight variability and cardiovascular outcomes: a systematic review and meta-analysis. Cardiovasc Diabetol. Published 9 January 2023. doi:10.
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