Weight loss is associated with improved daytime time in range in adults with prediabetes and non‐insulin‐treated type 2 diabetes undergoing dietary intervention
Authors' conclusion
Weight loss was associated with improved daytime TIR54-140 and TAR>140 in individuals with prediabetes and non-insulin-treated type 2 diabetes undergoing dietary intervention. The daytime time in tight range measures can complement traditional markers like HbA1c, offering a more comprehensive view of glycaemic variations during dietary weight loss programmes for individuals with prediabetes and type 2 diabetes not on insulin.
Study context
- Population
- Adults with prediabetes or non-insulin-treated T2D (HbA1c ≤ 8.0% [64 mmol/mol], diet alone or metformin); 63 ± 8 years, 62% female, BMI 33 ± 5 kg/m², HbA1c 5.8 ± 0.6%
- Participants
- 76 adults
- Comparison
- Change from baseline to 6 months; weight change vs tight range (TIR) change
- Primary endpoint
- Change in CGM-derived TIR54-140 (overall, daytime, overnight) and its association with weight loss
- Follow-up
- 6 months
Methodological details6-month intervention, continuous glucose monitoring (CGM) at baseline and 6 months, linear regression adjusted for demographic and clinical covariates
- 6-month intervention
- CGM at baseline and 6 months
- Linear regression adjusted for demographic and clinical covariates
Primary result
As reported in the abstract
- Overall TIR54-140 change
- 3.3% [0.3, 6.3]%; p = 0.03
- Daytime TIR54-140 change
- 3.8% [0.9, 6.8]%; p = 0.01
- Overnight TIR54-140 change
- 2.0% [−2.2, 6.1]%; p = 0.36
- Overall TIR54-140 increase per 5% points weight loss (adjusted)
- 3.2% points (p = 0.016)
- Daytime TIR54-140 increase per 5% points weight loss (adjusted)
- 3.5% points (p = 0.006)
Further findings
TAR>140 and TIR70-140 vs weight loss · 6 months
- Similar associations for TAR>140 but not TIR70-140
- No associations between weight loss and change in any overnight TIR measure
Original publication
Weight loss is associated with improved daytime time in range in adults with prediabetes and non‐insulin‐treated type 2 diabetes undergoing dietary intervention. Diabet Med. Published 3 June 2025. doi:10.
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