Weight change and risk of incident type 2 diabetes: short, medium and long-term follow-up in tehran lipid and glucose study
Authors' conclusion
Weight gain and loss of ≥ 5% were associated with increased and decreased risks of incident T2DM, respectively, regardless of attained weight. This association was consistent over various follow-up durations among the Iranian population as recommended by guidelines.
Study context
- Population
- Iranian adults aged ≥20 years free of T2D or cancer at baseline (2002–2005), Tehran Lipid and Glucose Studymen = 2567
- Participants
- 6,930 adults
- Exposure
- ≥5% weight gain or ≥5% weight loss vs stable weight over 3 years
- Outcome
- Incident T2D
- Follow-up
- 3-, 6- and 9-year follow-up
Methodological detailspopulation-based, Tehran Lipid and Glucose Study, Generalized Estimating Equations (GEE) multivariable-adjusted
- Population-based
- Tehran Lipid and Glucose Study
- GEE multivariable-adjusted
Main finding
As reported in the abstract
median follow-ups of 3, 6 and 9 years
Each group vs stableOdds ratio (95% CI)
≥ 5% gain3-year follow-up
1.58(1.16–2.14)
≥ 5% gain6-year follow-up
1.76(1.41–2.20)
≥ 5% gain9-year follow-up
1.70(1.40–2.05)
≥ 5% loss3-year follow-up
0.48(0.29–0.80)
≥ 5% loss6-year follow-up
0.57(0.40–0.81)
≥ 5% loss9-year follow-up
0.51(0.38–0.68)
- T2D cases at 3-, 6- and 9-year follow-ups
- 295, 505, and 748
Observational data: associations, not effects.
Further findings
Subgroups by age, gender and BMI
- Consistent associations across age, gender and BMI categories
Original publication
Weight change and risk of incident type 2 diabetes: short, medium and long-term follow-up in tehran lipid and glucose study. Cardiovasc Diabetol. Published 18 June 2024. doi:10.
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