Waist-to-height ratio as a non-invasive marker of renal sinus fat: a MRI-based cohort study
Authors' conclusion
Adiposity measures incorporating waist circumference are associated with RSF independent of BMI. While RSF exhibits a stronger relationship with adiposity measures, RSF% predicts eGFR. Both metrics offer complementary insights and should be considered in future studies.
Study context
- Population
- Individuals with severe obesity and lean volunteers; Renal sinus fat (RSF) and RSF% assessed via MRI50 re-evaluated after bariatric surgery
- Participants
- 74 vs 47
- Exposure
- Adiposity indices vs BMI for prediction of RSF; severe obesity vs lean; before vs after bariatric surgery
- Severe obesityn = 74
- Leann = 47reference
- Outcome
- Association of adiposity indices with RSF and RSF% (vs BMI)
Methodological detailsMRI-based
- MRI-based
Main finding
As reported in the abstract
Association of adiposity indices with RSF (multivariable regression adjusted for age, sex and BMI)
- Body Roundness Index (BRI), waist-to-height ratio (WHtR) and waist circumference showed the strongest associations with RSF
- Only WHtR was significantly associated with RSF%
Observational data: associations, not effects.
Further findings
RSF and RSF% vs estimated glomerular filtration rate (eGFR)
- Univariate: RSF and RSF% inversely correlated with eGFR
- Multivariate: only RSF% independently associated with eGFR
RSF change after bariatric surgery · 6 to 12 months after bariatric surgery
- RSF change correlated with changes in WHtR and BRI
Original publication
Waist-to-height ratio as a non-invasive marker of renal sinus fat: a MRI-based cohort study. Int J Obes (Lond). Published 13 December 2025. doi:10.
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