Is hyperdynamic circulation a hallmark of obesity?
Authors' conclusion
Higher BMI is significantly associated with increased CI and decreased SVR, indicating a hyperdynamic circulatory state in obesity. These findings suggest a potential hemodynamic mechanism linking obesity to cardiovascular risk.
Study context
- Population
- Adults admitted for medical reasons to the ED of a large tertiary care hospital in Copenhagen, Denmark, 2019–2023; mean age 64 years, 44% female
- Participants
- 942 adults
- Exposure
- Obesity vs no obesity
- Obesityn = 187
- Outcome
- Association of BMI with cardiac index (CI) and systemic vascular resistance (SVR), by non-invasive pulse wave analysis (Finapres® NOVA)
- Follow-up
- Within 24 hours of admission
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
CI higher with obesity vs without obesity (p < 0.0001)
16%
Systemic vascular resistance (SVR) lower with obesity vs without obesity (p < 0.0001)
23%
Rise in CI per 5 kg/m² increase in body mass index (BMI) (p < 0.0001)
7.7%
Decrease in SVR per 5 kg/m² increase in BMI (p < 0.0001)
12.7%
Observational data: associations, not effects.
Original publication
Is hyperdynamic circulation a hallmark of obesity? Int J Obes (Lond). Published 12 December 2025. doi:10.
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