Prolonged Endurance Exercise Increases Macrophage Content and Mitochondrial Respiration in Adipose Tissue in Trained Men
Authors' conclusion
Overall, we found a positive effect of prolonged endurance exercise on adipose tissue inflammation markers and mitochondrial respiration in both young and old trained men, and no sign of attenuated function in adipose tissue with age.
Study context
- Population
- Trained men, young (30 years) and old (65 years); 15 consecutive days biking 7 to 9 hours/day from Copenhagen, Denmark to Palermo, Italy
- Participants
- 7 vs 7
- Comparison
- Before vs after 15 days of prolonged endurance cycling, in young and old trained men
- Youngn = 7
- Oldn = 7
- Outcome
- Adipose tissue inflammation markers and mitochondrial respiration
- Follow-up
- After the 15-day intervention vs before
Methodological detailsbefore-after design, Gluteal and abdominal adipose tissue sampled before and after the intervention; mitochondrial respiration by high-resolution respirometry; inflammation by immunohistochemical staining
- Before-after design
- Gluteal and abdominal adipose tissue sampled before and after the intervention; mitochondrial respiration by high-resolution respirometry; inflammation by immunohistochemical staining
Main finding
As reported in the abstract
after the 15-day intervention vs before
- Increased number of CD163+ macrophages in both gluteal and abdominal depot
- P < .01
- Young: increased abdominal adipose tissue mitochondrial respiration with CIp, CI+IIp stimulated respiration and electron transport system (ETS) capacity
- P < .05
- Old: increase in abdominal CIp and CI+IIp stimulated respiration
- P < .05
Original publication
Prolonged Endurance Exercise Increases Macrophage Content and Mitochondrial Respiration in Adipose Tissue in Trained Men. J Clin Endocrinol Metab. Published 29 August 2023. doi:10.
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