Association between visceral obesity and tumor recurrence in hepatocellular carcinoma recipients undergoing liver transplantation
Authors' conclusion
Both recipient VSR and donor VSR were significant risk factors for HCC recurrence and mortality in LDLT recipients. Preoperative donor VSR and recipient VSR may be strong predictors of the surgical outcomes of LDLT recipients with HCC.
Study context
- Population
- Donor–recipient sets undergoing living donor liver transplantation (LDLT) for hepatocellular carcinoma (HCC), January 2008–January 2018
- Participants
- 1,386 donor–recipient sets
- Exposure
- High vs low visceral-to-subcutaneous fat area ratio (VSR) in donors and recipients
- Outcome
- Overall HCC recurrence and mortality in recipients
Main finding
As reported in the abstract
Estimate (95% CI)P value
High donor VSRvs Low donor VSR
aHR (HCC recurrence) 1.43(1.06–1.93)
P = 0.019High donor VSRvs Low donor VSR
HR (mortality) 1.35(1.03–1.76)
P = 0.030High recipient VSRvs Low recipient VSR
HR (HCC recurrence) 1.40(1.04–1.88)
P = 0.027High recipient VSRvs Low recipient VSR
HR (mortality) 1.50(1.14–1.96)
P = 0.003Observational data: associations, not effects.
Original publication
Association between visceral obesity and tumor recurrence in hepatocellular carcinoma recipients undergoing liver transplantation. Int J Obes (Lond). Published 28 August 2023. doi:10.
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