Identification of myokines susceptible to improve glucose homeostasis after bariatric surgery
Authors' conclusion
Improved glucose homeostasis following bariatric surgery is associated with changes in myokines expression and circulating levels. In particular, upregulation of BDNF, XYLT1, SPINK5, and LGR5 is associated with improved insulin sensitivity. These results suggest that these myokines could contribute to improved glucose homeostasis following bariatric surgery.
Study context
- Population
- Patients undergoing bariatric surgery
- Comparison
- After vs before bariatric surgery
- Outcome
- Changes in myokines and associations with homeostasis model assessment (HOMA) changes
- Follow-up
- 3 months after bariatric surgery
Methodological detailsbefore–after (before and 3 months after bariatric surgery), targeted and untargeted (RNA-sequencing) analyses
- Before–after (before and 3 months after bariatric surgery)
- Targeted and untargeted (RNA-sequencing) analyses
Main finding
As reported in the abstract
3 months after bariatric surgery
- Targeted: Brain-derived neurotrophic factor (BDNF) expression upregulated
- +30%, P = .006
- Targeted: BDNF circulating levels decreased
- −12%, P = .001
- Upregulated BDNF expression associated with decreased HOMA of insulin resistance (HOMA-IR)
- adjusted estimate −0.51 [−0.88 to −0.13], P = .010 (95% CI)
- Decreased BDNF serum levels associated with decreased HOMA-B
- adjusted estimate 0.002 [0.00002-0.0031], P = .046 (95% CI)
- Untargeted: XYLT1 upregulated
- +64%, P < .001
- Untargeted: LGR5 upregulated
- +57, P< .001
- Untargeted: SPINK5 upregulated
- +46%, P < .001
- Upregulated LGR5 associated with decreased HOMA-IR
- adjusted estimate −0.50 [−0.86 to −0.13], P = .009 (95% CI)
- Upregulated XYLT1 associated with increased HOMA-S
- adjusted estimate 109.1 [28.5-189.8], P = .009 (95% CI)
- Upregulated SPINK5 associated with increased HOMA-S
- adjusted estimate 16.5 [0.87-32.19], P = .039 (95% CI)
Original publication
Identification of myokines susceptible to improve glucose homeostasis after bariatric surgery. Eur J Endocrinol. Published 28 August 2023. doi:10.
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