The Physiology Of the WEight Reduced State (POWERS) study: overview and study design
Study context
- Population
- Adults with obesity undergoing a behavioral weight loss (WL) intervention; those losing ≥7% of pre-intervention weight and attaining weight stability enter a 1-year observational phaseenrolled
- Participants
- 205 adults
- Primary endpoint
- Weight change during the observational period, with primary independent variables measuring energy intake and energy expenditure
- Follow-up
- 1-year observational phase
Methodological detailsbehavioral WL intervention followed by 1-year observational phase, two clinical centers, Anticipated: 70% of enrolled enter the observational phase and 100 complete the study, Energy intake and expenditure endophenotypes assessed by biospecimens, neuroimaging, objective measures (doubly labeled water, calorimetry, accelerometry, polysomnography), questionnaires and interviews
- Behavioral WL intervention followed by 1-year observational phase
- Two clinical centers
- Anticipated: 70% of enrolled enter the observational phase and 100 complete the study
- Energy intake and expenditure endophenotypes assessed by biospecimens, neuroimaging, objective measures (doubly labeled water, calorimetry, accelerometry, polysomnography), questionnaires and interviews
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
The Physiology Of the WEight Reduced State (POWERS) study: overview and study design. Int J Obes (Lond). Published 12 December 2025. doi:10.
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