The Physiology Of the WEight Reduced State (POWERS) study: strategies for the analysis of biological specimens
Study context
- Population
- Healthy US adults aged 25–59 years, body mass index (BMI) 30- ≤ 40 kg/m², after ≥7% supervised weight loss via lifestyle interventionplanned
- Participants
- 205 adults
- Primary endpoint
- Weight change (weight regain) following ≥7% supervised weight loss
- Follow-up
- T0 to T12 (one year)
Methodological detailsBiospecimens collected at baseline (BL), immediately after weight loss (T0), and 4 (T4) and 12 (T12) months after weight loss, Blood collected fasting and after a meal challenge designed to induce satiety hormones, Biospecimens: plasma, serum, peripheral blood mononuclear cells (PBMCs), DNA, urine, feces, adipose and skeletal muscle tissue; biobanked at each site
- Biospecimens collected at baseline (BL), immediately after weight loss (T0), and 4 (T4) and 12 (T12) months after weight loss
- Blood collected fasting and after a meal challenge designed to induce satiety hormones
- Biospecimens: plasma, serum, PBMCs, DNA, urine, feces, adipose and skeletal muscle tissue; biobanked at each site
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
The Physiology Of the WEight Reduced State (POWERS) study: strategies for the analysis of biological specimens. Int J Obes (Lond). Published 5 February 2026. doi:10.
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