Vitamin E Intake and Prevalence Rates of Thyroid Dysfunction and Autoimmune Thyroiditis: A Cross-Sectional Analysis of National Health and Nutrition Examination Survey (NHANES) Data
Main finding · Prevalence of SCHResult — go to the resultOdds ratio 0.28 CI 0.15–0.54Authors' conclusion
The findings of this study suggest that a higher intake of vitamin E is associated with lower prevalence rates of SCH and autoimmune thyroiditis among males.
Study context
- Population
- Nonpregnant adults without preexisting thyroid diseases with complete thyroid and vitamin E data, NHANES 2007–2012
- Participants
- 7,773 adults
- Exposure
- Dietary vitamin E intake tertiles
- Outcome
- Prevalence of SCH
Methodological detailsNHANES 2007–2012, complex multistage probability sampling design, weighted multinomial logistic regression, restricted cubic splines
- NHANES 2007–2012
- Complex multistage probability sampling design
- Weighted multinomial logistic regression
- Restricted cubic splines
Main finding
As reported in the abstract
Odds ratio
0.28
CI 0.15–0.54
P < 0.001
By group
T3vs T1
OR 0.28 (CI 0.15–0.54); P < 0.001
- Decreasing trend in subclinical hypothyroidism (SCH) prevalence across tertiles
- P for trend = 0.013
Observational data: associations, not effects.
Further findings
| Outcome | OR (CI) | P value | |
|---|---|---|---|
| Prevalence of SCH, males (subgroup)T2vs T1 | 0.45 (0.23–0.87) | P = 0.020 | |
| Prevalence of SCH, males (subgroup)T3vs T1 | 0.19 (0.09–0.39) | P < 0.001 | |
| Prevalence of autoimmune thyroiditis (AIT), males (subgroup)T2vs T1 | 0.59 (0.37–0.93) | P = 0.024 | |
| Prevalence of autoimmune thyroiditis (AIT), males (subgroup)T3vs T1 | 0.52 (0.36–0.75) | P < 0.001 | |
| 0.050.21520Odds ratio (log scale) |
Females (subgroup)
- No significant association observed among females
Original publication
Vitamin E Intake and Prevalence Rates of Thyroid Dysfunction and Autoimmune Thyroiditis: A Cross-Sectional Analysis of NHANES Data. Thyroid. Published 8 April 2024. doi:10.
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