Thyroid Autoimmunity is Associated with Dietary Fat Consumption
Authors' conclusion
We found a strong association between fat consumption and thyroid autoimmunity in the overall population and men from the nationally representative population-based survey. Fat and fatty acid consumption may be of benefit to individuals with thyroid autoimmunity.
Study context
- Population
- Adults aged ≥20 years in US NHANES 2007–2012 with valid TPOAb, TgAb and fat intake data3,949 men · 3,964 women
- Participants
- 7,913 adults
- Exposure
- Fat and specific fatty acid intake vs thyroid autoimmunity
- Outcome
- Thyroid autoimmunity (TgAb and TPOAb seropositivity)
Methodological detailsnationally representative population-based survey, multivariable regression
- Nationally representative population-based survey
- Multivariable regression
Main finding
As reported in the abstract
Association of fat intake with thyroid autoimmunity, men, after full adjustment
Total fat: OR
0.64
95% CI 0.49–0.83
Saturated fatty acid: OR
0.65
95% CI 0.51–0.84
Monounsaturated fatty acid: OR
0.65
95% CI 0.50–0.85
Polyunsaturated fatty acid: OR
0.76
95% CI 0.57–0.995
Observational data: associations, not effects.
Further findings
Seropositivity prevalence
- TgAb seropositivity
- 7.5%
- TPOAb seropositivity
- 11.9%
- TgAb and TPOAb seropositivity more common with low-fat intake
TgAb and TPOAb seropositivity separately
- Fats associated with TgAb seropositivity in overall population and men
- Fats associated with TPOAb seropositivity only in overall population
Original publication
Thyroid Autoimmunity is Associated with Dietary Fat Consumption. J Clin Endocrinol Metab. Published 12 September 2024. doi:10.
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