Vitamin D deficiency increases the risk of diabetic peripheral neuropathy in elderly type 2 diabetes mellitus patients by predominantly increasing large-fiber lesions
Authors' conclusion
VDD is independently associated with a higher risk of DPN. VDD may promote the development of DPN by affecting large nerve fibers.
Study context
- Population
- Elderly T2D patients; Vitamin D deficiency (VDD) defined as serum 25(OH)D <20 ng/ml
- Participants
- 257 patients
- Exposure
- Diabetic peripheral neuropathy (DPN) vs non-DPN; VDD vs vitamin D-sufficient
- Outcome
- Serum 25(OH)D
Methodological detailspropensity score matching (age, sex, diabetes duration)
- Propensity score matching (age, sex, diabetes duration)
Main finding
As reported in the abstract
P = 0.018
Observational data: associations, not effects.
Further findings
| Outcome | OR | P value |
|---|---|---|
| VDD as independent risk factor for DPNMultivariate logistic regression | 2.488 | P = 0.008 |
| Prolongation of median motor nerve latency | 1.362 | P = 0.038 |
Correlation of serum 25(OH)D with nerve conduction
- Spearman's correlation: negative with specific nerve latencies; positive with specific nerve velocities and amplitudes
Nerve latencies, VDD vs vitamin D-sufficient
- VDD had longer median sensory nerve latencies and motor evoked potential latencies vs vitamin D-sufficient
Original publication
Vitamin D deficiency increases the risk of diabetic peripheral neuropathy in elderly type 2 diabetes mellitus patients by predominantly increasing large-fiber lesions. Diabetes Res Clin Pract. Published 15 February 2024. doi:10.
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