Variation in effectiveness of the NHS Diabetes Prevention Programme in people diagnosed with non‐diabetic hyperglycaemia by age, sex, BMI , and deprivation: A matched cohort analysis of 69,801 people
Authors' conclusion
The DPP was effective in reducing conversion rates from NDH to diabetes as shown in our previous study results. The intervention appeared to be similarly effective by age, sex, BMI, and deprivation.
Study context
- Population
- Adults diagnosed with non-diabetic hyperglycaemia (NDH)matched cohort
- Participants
- 18,470 vs 51,331
- Exposure
- Referral to the NHS Diabetes Prevention Programme (DPP) vs matched controls, by age, sex, BMI and deprivation
- DPPn = 18,470
- Controlsn = 51,331reference
- Outcome
- Conversion to diabetes; heterogeneity of DPP effect by age, sex, BMI and IMD (interactions)
Methodological detailsrandom-effects parametric survival models, interactions fitted for age, sex, BMI and IMD
- Random-effects parametric survival models
- Interactions fitted for age, sex, BMI and IMD
Main finding
As reported in the abstract
Interaction of patient characteristics with DPP referral on conversion to diabetes
Hazard ratio (95% CI)P value
Womenvs Mendifference in HR of conversion
0.94(0.81–1.08)
P = 0.38Aged [18-34]vs Aged [55-64]
0.79(0.34–1.84)
P = 0.58Aged [75-84]vs Aged [55-64]
0.86(0.66–1.12)
P = 0.26BMI ≥ (25-29.9) kg/m²vs BMI < 25 kg/m²
0.88(0.62–1.26)
P = 0.49BMI ≥ 30 kg/m²vs BMI < 25 kg/m²
0.76(0.54–1.06)
P = 0.10Most deprived IMD quintilevs Least deprived IMD quintile
1.31(0.98–1.73)
P = 0.06Observational data: associations, not effects.
Original publication
Variation in effectiveness of the NHS Diabetes Prevention Programme in people diagnosed with non‐diabetic hyperglycaemia by age, sex, BMI , and deprivation: A matched cohort analysis of 69,801 people. Diabet Med. Published 18 April 2025. doi:10.
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