Sex differences in myocardial flow reserve among individuals with type 2 diabetes: insights from the DiaHeart study
Authors' conclusion
In individuals with type 2 diabetes without overt CVD, women exhibited lower MFR than men, primarily due to higher MBF at rest, suggesting sex-related differences. While MFR declined in both sexes, the sex difference was more pronounced in younger individuals and diminished over time. These findings underscore the need for further research into sex-specific thresholds for MFR in cardiovascular risk stratification.
Study context
- Population
- Individuals with T2D without overt cardiovascular disease (CVD), recruited 2020–2023; mean age 65 years, diabetes duration 14 years
- Participants
- 901 individuals
- Exposure
- Women vs men
- Womenn = 266
- Outcome
- MBF at rest and during pharmacologically induced stress and MFR by 82-Rubidium PET/CT
Main finding
As reported in the abstract
MFR
Women
2.44
mean · SD 0.67
Men
2.59
mean · SD 0.77
P = 0.003
Observational data: associations, not effects.
Further findings
MFR < 2
| Outcome | Estimate |
|---|---|
| MFR difference by age (sex × age)Lower with women | mean MFR difference at age 55 0.29 (95% CI - 0.44 to - 0.14) |
| MFR difference by age (sex × age) | difference at age 75 - 0.04 (95% CI - 0.19 to 0.11) |
- Myocardial flow reserve (MFR) difference by age (sex × age) — Sex × age interaction after adjustment for other risk factors not statistically significant
- p = 0.057
MFR < 2
- Similar proportion of men and women had MFR < 2
MFR difference by age (sex × age)
- No other risk factors exhibited significant sex-dependent interactions
Original publication
Sex differences in myocardial flow reserve among individuals with type 2 diabetes: insights from the DiaHeart study. Cardiovasc Diabetol. Published 18 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →