Variants within the lipoprotein lipase (LPL) gene confer susceptility to diabetic kidney disease and rapid decline in kidney function in Chinese patients with type 2 diabetes
Authors' conclusion
These results suggest that LPL-related SNPs are new candidate factors for conferring susceptibility to DKD and may promote rapid loss of renal function in Chinese patients with T2D.
Study context
- Population
- Chinese patients with T2D from the third China National Stroke Registry
- Participants
- 2,793 patients
- Outcome
- Diabetic kidney disease (DKD) (urine albumin-to-creatinine ratio (UACR) ≥30 mg/g or eGFR <60 mL/min/1.73 m² at baseline and 3 months)
Methodological detailsadditive model, logistic regression
- Additive model
- Logistic regression
Main finding
As reported in the abstract
DKD defined by eGFR
rs285 C>T, OR (P = .0154)
1.40
rs328 C>G, OR (P = .0104)
2.24
rs3208305 A>T, OR (P = .0015)
1.85
Further findings
Rapid decline in kidney function (RDKF) (estimated glomerular filtration rate (eGFR) reduction ≥3 mL/min/1.73 m² per year) · mean follow-up 1 year
- Participants with RDKF among 1241 with follow-up data
- 441 (35.5%)
- rs285 C allele, adjusted OR for RDKF
- 1.31 (95% CI 1.04-1.66; P = .025)
- Adjusted for multiple variables
Original publication
Variants within the LPL gene confer susceptility to diabetic kidney disease and rapid decline in kidney function in Chinese patients with type 2 diabetes. Diabetes Obes Metab. Published 10 July 2023. doi:10.
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