Gestational diabetes & diabetes in pregnancy
The utility of plasma glycated CD59 in predicting postpartum glucose intolerance: A prospective study of women diagnosed with GDM during a period of universal GDM screening
Authors' conclusion
Our study found that PP pGCD9 may be a promising biomarker to identify women not requiring PP glucose intolerance screening using the traditional OGTT. While the diagnostic accuracy of pGCD59 is good, fasting plasma glucose remains a better test for the identification of PP glucose intolerance.
Study context
- Population
- Women with prior GDM (World Health Organization (WHO) 2013 criteria, 2 h 75 g OGTT at 24–28 weeks) during universal GDM screening; PP glucose intolerance by 2 h 75 g OGTT, ADA criteriaof 2017 recruited
- Participants
- 140 women
- Comparison
- PP Plasma glycated CD59 (pGCD59) vs PP FPG for predicting PP glucose intolerance
- Outcome
- Ability of PP pGCD59 to predict PP glucose intolerance (2 h 75 g OGTT, ADA criteria), by nonparametric ROC curves
- Follow-up
- Postpartum
Performance
As reported in the abstract
Identification of PP glucose intolerance
| Test or model | AUC | Sensitivity at cut-off 1.9 SPU | Specificity at cut-off 1.9 SPU | PPV at cut-off 1.9 SPU | NPV at cut-off 1.9 SPU |
|---|---|---|---|---|---|
| PP pGCD59 | 0.80 (95% CI: 0.70-0.91) | 100% (95% CI: 83.9-100) | 16.9% (95% CI: 9.8-26.3) | 22.1% (95% CI: 21.0-22.6) | 100% (95% CI: 87.4-100) |
| PP FPG | 0.96 (95% CI: 0.89-0.99) | — not stated in the abstract | — not stated in the abstract | — not stated in the abstract | — not stated in the abstract |
AUC
PP pGCD590.80 (95% CI: 0.70-0.91)
PP FPG0.96 (95% CI: 0.89-0.99)
Sensitivity at cut-off 1.9 SPU
PP pGCD59100% (95% CI: 83.9-100)
PP FPG— not stated in the abstract
Specificity at cut-off 1.9 SPU
PP pGCD5916.9% (95% CI: 9.8-26.3)
PP FPG— not stated in the abstract
PPV at cut-off 1.9 SPU
PP pGCD5922.1% (95% CI: 21.0-22.6)
PP FPG— not stated in the abstract
NPV at cut-off 1.9 SPU
PP pGCD59100% (95% CI: 87.4-100)
PP FPG— not stated in the abstract
— not stated in the abstract
Further findings
PP pGCD59 levels: PP glucose intolerance vs normal glucose tolerance · postpartum
PP pGCD59 levels: PP glucose intolerance vs normal glucose tolerance · postpartum
- Significantly higher PP pGCD59 with PP glucose intolerance
Original publication
The utility of plasma glycated CD59 in predicting postpartum glucose intolerance: A prospective study of women diagnosed with GDM during a period of universal GDM screening. Diabet Med. Published 2 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →