Gestational diabetes & diabetes in pregnancy
Prepregnancy BMI, gestational weight gain, and susceptibility to autism‐related traits: the Early Autism Risk Longitudinal Investigation (EARLI) and Health Outcomes and Measures of the Environment (HOME) studies
Authors' conclusion
GWG may be associated with autism-related behaviors among children who have a greater predisposition to these behaviors and who have mothers with prepregnancy overweight or obesity.
Study context
- Population
- Mothers and their children aged 3 to 8 years; ASD-related traits assessed by caregiver-completed Social Responsiveness Scale (SRS)
- Participants
- 136 vs 253
- Exposure
- Gestational weight gain (GWG) z scores vs ASD-related traits in children
- EARLIn = 136
- HOMEn = 253
- Outcome
- Association between gestational age and prepregnancy BMI category-specific GWG z scores and ASD-related behaviors (SRS scores)
- Follow-up
- Children aged 3 to 8 years
Methodological detailstwo cohorts: familial enriched (EARLI) and general population (HOME), quantile regression
- Two cohorts: familial enriched (EARLI) and general population (HOME)
- Quantile regression
Main finding
As reported in the abstract
Association of GWG z scores with SRS scores
- HOME, mothers with prepregnancy overweight or obesity: GWG z scores positively associated with SRS scores in children with more ASD-related traits (higher SRS scores), but not in children with fewer ASD-related traits
- EARLI, mothers with prepregnancy obesity: similar patterns observed
Observational data: associations, not effects.
Original publication
Prepregnancy BMI, gestational weight gain, and susceptibility to autism‐related traits: the EARLI and HOME studies. Obesity (Silver Spring). Published 26 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →