Gestational diabetes & diabetes in pregnancy
Utility of In Vivo Magnetic Resonance Imaging Is Predictive of Gestational Diabetes Mellitus During Early Pregnancy
Authors' conclusion
A combination of MRI-based placental volume, perfusion, and visceral adiposity during early pregnancy demonstrates significant changes in GDM and provides a proof of concept for predicting the subsequent development of GDM.
Study context
- Population
- Pregnant women recruited in the first trimester at UCLA outpatient antenatal obstetrics clinics, followed until parturition
- Participants
- 186 women
- Exposure
- GDM vs control
- GDMn = 21
- Outcome
- Prediction of GDM by combined MRI placental volume, perfusion and visceral adiposity (AUC)
- Follow-up
- 14 to 16 weeks and 19 to 24 weeks GA
Methodological detailssingle-centre, prospective magnetic resonance imaging (MRI) at 14–16 and 19–24 weeks gestational age (GA)
- Single-centre
- Prospective MRI at 14–16 and 19–24 weeks GA
Main finding
As reported in the abstract
Prediction of GDM: combined VFAR, placental volume and perfusion
- AUC at 14 to 16 weeks
- 0.83
- PPV at 14 to 16 weeks
- 0.77
- NPV at 14 to 16 weeks
- 0.83
- AUC at 19 to 24 weeks GA
- 0.81
- PPV at 19 to 24 weeks GA
- 0.73
- NPV at 19 to 24 weeks GA
- 0.86
Observational data: associations, not effects.
Further findings
- GDM incidence
- 11.3% · 21
- Visceral fat area ratio (VFAR) · 14 to 16 and 19 to 24 weeks GA · higher with GDM
- P < 0.001 each
- Placental volume · 19 to 24 weeks GA · greater with GDM
- P = 0.01
Original publication
Utility of In Vivo Magnetic Resonance Imaging Is Predictive of Gestational Diabetes Mellitus During Early Pregnancy. J Clin Endocrinol Metab. Published 17 October 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →