Using a Composite Summary of Daily Sex Hormones to Gauge Time Until Menopause: A Focus on Pregnanediol Glucuronide (PDG)
Authors' conclusion
Since PDG is generally not considered a predictor/descriptor of ovarian aging, this work validates the DTW/FuzzEn analytical framework and introduces another metric/hormone to be used in FMP-related preventive care.
Study context
- Population
- Multiracial sample of mid-life women, Study of Women's Health Across the Nation
- Participants
- 549 participants
- Outcome
- Relationship between daily hormone trajectories (FuzzEn and DTW from premenopausal/stable cycle gold standard) and time to FMP
Methodological detailsdaily urinary hormone measurement over one menstrual cycle, cluster analyses, Cox proportional hazards analyses, Urinary luteinizing hormone (LH), follicle-stimulating hormone (FSH), estrogen conjugates (E1C) and PDG measured daily for one menstrual cycle
- Daily urinary hormone measurement over one menstrual cycle
- Cluster analyses
- Cox proportional hazards analyses
- Urinary LH, FSH, E1C and PDG measured daily for one menstrual cycle
Main finding
As reported in the abstract
Time to FMP
- PDG stands out as a powerful predictor/descriptor of time to final menstrual period (FMP)
- Clusters of PDG on the DTW/Fuzzy entropy (FuzzEn) plane yield statistically different survival curves
- Separation persists in Cox analyses adjusted for FSH, AMH, age, BMI, financial hardship, smoking status and cycle length
Observational data: associations, not effects.
Original publication
Using a Composite Summary of Daily Sex Hormones to Gauge Time Until Menopause: A Focus on Pregnanediol Glucuronide (PDG). J Clin Endocrinol Metab. Published 23 January 2025. doi:10.
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