Use of the Omnipod 5 Automated Insulin Delivery System Activity Feature Reduces Insulin Delivery and Attenuates the Drop in Glycemia Associated With Exercise in a Randomized Controlled Trial
An erratum to this article was published (Diabetes Care, 1 Jan 2026 ↗)
Authors' conclusion
Enabling the Activity feature either 60 or 30 min before exercise reduced insulin delivery and attenuated glucose drops relative to Auto, but hypoglycemia incidence was not different across the three conditions. These findings support the use of the Omnipod 5 System for exercise but highlight the importance of using additional strategies, such as earlier use of Activity feature and/or carbohydrate intake to further reduce hypoglycemia risk.
Study context
- Population
- Adults and adolescents with T1D wearing the Omnipod 5 System, from the extension phase of its pivotal trial; age 30 ± 15 years, BMI 24.7 ± 4.1 kg/m², HbA1c 7.5% ± 0.9%; 70-min treadmill session at 64–76% maximum heart rate, postabsorptivecrossover
- Participants
- 38 adults
- Comparison
- Activity feature enabled 60 min (AF-60) or 30 min (AF-30) before exercise vs automated mode (Auto)
Methodological detailsthree-way crossover
- Three-way crossover
Primary result
As reported in the abstract
AF-60 vs Auto: P = 0.34 · AF-30 vs Auto: P = 0.14
Further findings
| Outcome | AF-60 | AF-30 | Auto | P value |
|---|---|---|---|---|
| Glucose drop during exerciseAF-60 vs Auto · attenuated glucose drop | −44 ± −33 mg/dL | −36 ± −34 mg/dL | −57 ± −35 mg/dL | P = 0.02 |
| Glucose drop during exerciseAF-30 vs Auto · attenuated glucose drop | P = 0.01 |
- Insulin delivery · hour before and during exercise · AF-60 and AF-30 vs Auto · reduced, hour before exercise
- P < 0.001
- Insulin delivery · hour before and during exercise · AF-60 and AF-30 vs Auto · reduced, during exercise
- P < 0.001
Glycemia and insulin delivery postexercise · 4-h postexercise period
- Glycemia and insulin delivery were comparable
Original publication
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