Factors of Composite Target of Time in Range and Time Below Range Among Children and Adolescents With Type 1 Diabetes Mellitus Using Open-Source Automated Insulin Delivery
Authors' conclusion
T1DM children and adolescents with older age, shorter T1DM duration at AAPS initiation, and higher meal announcement frequency during AAPS use had the potential to successfully achieve composite target.
Study context
- Population
- Children and adolescents aged <18 years with T1D who used open-source Android artificial pancreas system (AAPS) for ≥6 months; median age 10.64 years, baseline HbA1c 7.78 ± 2.12%44.16% male
- Participants
- 77 children
- Outcome
- Achievement of composite:
- Target (TIR 70-180 mg/dL >70% and TBR 70 mg/dL <4%)
- Its associated factors
- Follow-up
- 6 months
Main finding
As reported in the abstract
Factors associated with achieving composite target (logistic regression)
Age at AAPS initiation, OR (P < .05)
1.32
T1D duration, OR (P < .05)
0.72
Frequency of daily meal announcements, OR (P < .05)
1.40
Composite target achieved at 6 months
35.06%
Observational data: associations, not effects.
Further findings
Composite target achieved · 3 months
- Achievement rate at 3 months
- 41.56%
- Decline to 6 months, P
- P > 0.05
TIR>70% achieved · 3 and 6 months
- 3 months
- 67.53%
- 6 months
- 66.23%
TBR70 <4% achieved · 3 and 6 months
- 3 months
- 57.14%
- 6 months
- 54.55%
Original publication
Factors of Composite Target of Time in Range and Time Below Range Among Children and Adolescents With Type 1 Diabetes Mellitus Using Open-Source Automated Insulin Delivery. Endocr Pract. Published 15 July 2025. doi:10.
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