Real-World Safety and Effectiveness of U200 Insulin Use in Automated Insulin Delivery Systems in Adolescents and Young Adults with Type 1 Diabetes
Authors' conclusion
These data suggest that U200-AID is a viable option for individuals with T1D and high insulin requirements.
Study context
- Population
- And young adults (AYAs) with T1D and high insulin requirements initiating use in AID (U200-AID) (age 15.4 years, T1D duration 5.5 years, HbA1c 8.5%)
- Participants
- 50 participants
- Exposure
- Post- vs pre-U200 concentrated insulin use in automated insulin delivery (AID)
- Outcome
- TIR (70-180 mg/dL)
Methodological detailstwo-center, pre-/post-U200-AID
- Two-center
- pre-/post-U200-AID
Main finding
As reported in the abstract
P = 0.012
Observational data: associations, not effects.
Further findings
Days between cartridge changes · increased
P < 0.001
Total daily insulin dose · increased
P < 0.001
TBR (<70 mg/dL)
- Did not change significantly
Safety
Severe hypoglycemia or DKA · median follow-up 290 days (IQR 227, 476)
- No severe hypoglycemia or DKA occurred
Original publication
Real-World Safety and Effectiveness of U200 Insulin Use in Automated Insulin Delivery Systems in Adolescents and Young Adults with Type 1 Diabetes. Diabetes Technol Ther. Published 18 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →