Use of the Loop Open-Source Automated Insulin Delivery System in Children with Type 1 Diabetes: Six-Month Results from a Single Center
Authors' conclusion
Use of the Loop OS-AID system resulted in improved glycemic outcomes without increased risk of hypoglycemia or diabetic ketoacidosis. These findings support Loop as a safe and effective alternative for pediatric T1D management. Further large-scale and longer term studies are warranted.
Study context
- Population
- Children aged 2–18 years with T1D duration ≥6 months who started Loop open-source AID (OS-AID) between May 2023 and May 2024
- Participants
- 50 children
- Exposure
- Loop OS-AID at 6 months vs baseline
- Loopn = 50
- Outcome
- TIR (3.9-10 mmol/L [70-180 mg/dL]), time above range (TAR), time below range (TBR), GMI and HbA1c
- Follow-up
- 6 months
Main finding
As reported in the abstract
Glycaemic outcomes, baseline vs 6 months
- Time in range (TIR) improved from baseline to 6 months
- 68.3% to 72.7% (p = 0.003)
- Participants with TIR >70%
- 46% to 66% (p = 0.012)
- Mean HbA1c, baseline vs month 6
- 53 mmol/mol [7.0%] vs. 49 mmol/mol [6.6%], p = 0.006
- TAR1 >10 mmol/L (180 mg/dL) decreased
- p < 0.001
- TAR2 >13.8 mmol/L (250 mg/dL): slight, nonsignificant reduction
- p = 0.363
- TBR1 <3.9 mmol/L (70 mg/dL) remained stable
- p1 = 0.474
- TBR2 <3 mmol/L (54 mg/dL) remained stable
- p2 = 0.560
Observational data: associations, not effects.
Further findings
Basal insulin ratio · 6 months
- Basal insulin ratio dropped significantly
- 40.3% vs. 19.7%, p < 0.001
Original publication
Use of the Loop Open-Source Automated Insulin Delivery System in Children with Type 1 Diabetes: Six-Month Results from a Single Center. Horm Res Paediatr. Published 27 January 2026. doi:10.
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