Efficacy and Safety of a Non-Carbohydrate Counting Meal Bolus Strategy in Adults with Type 1 Diabetes Using Open-Source Automated Insulin Delivery
Authors' conclusion
A non-CC meal bolus strategy based on preprandial glucose in adults with T1D utilizing open-source AID effectively prevents glycemic excursions and maintains a mean TIR over 70%.
Study context
- Population
- Adults with T1D aged 18 to 50 years using open-source AIDcrossover
- Participants
- 32 adults
- Comparison
- Closed loop (automatic mode) vs open loop (manual mode) open-source AID, with a non-carbohydrate counting meal bolus strategy
- Primary endpoint
- TIR
Methodological details7-day run-in, 2-week phases
- 7-day run-in
- 2-week phases
Primary result
As reported in the abstract
TIR, 24 h
P = 0.019
Further findings
TIR, night · TIR higher with closed loop; effect more pronounced at night
P < 0.001
Time to peak postprandial blood glucose · delayed with closed loop
P < 0.001
Average postprandial and peak blood glucose
- No significant differences between closed-loop and open-loop phases
Safety
Hypoglycemic events (＜3.9 mmol/L)
- Frequency of 24-h hypoglycemic events reduced in closed-loop vs open-loop phase
- No difference in nocturnal hypoglycemic events
Original publication
Efficacy and Safety of a Non-Carbohydrate Counting Meal Bolus Strategy in Adults with Type 1 Diabetes Using Open-Source Automated Insulin Delivery. Diabetes Technol Ther. Published 22 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →