Urinary albumin-to-creatinine ratio and incident type 2 diabetes: a 13.8-year cohort study of 411,389 UK biobank participants
Authors' conclusion
This large-scale cohort study demonstrates that microalbuminuria serves as a clinical predictor of elevated risk for incident T2DM in adults. Routine UACR screening in high-risk populations may enhance early detection and intervention.
Study context
- Population
- UK Biobank participants with baseline urine albumin-to-creatinine ratio (UACR) measurements
- Participants
- 411,389 participants
- Exposure
- UACR 3-30 mg/mmol and UACR > 30 mg/mmol vs UACR <3 mg/mmol
- Outcome
- Incident T2D
- Follow-up
- Average 13.8 years (range: 13.1-14.6 years)
Methodological detailsUK Biobank, Cox proportional hazards regression, restricted cubic spline analyses
- UK Biobank
- Cox proportional hazards regression
- Restricted cubic spline analyses
Main finding
As reported in the abstract
average follow-up 13.8 years
Each group vs UACR <3 mg/mmolHazard ratio (95% CI)
UACR 3-30 mg/mmol
1.31(1.17–1.45)
UACR > 30 mg/mmol
2.20(1.58–3.06)
- New cases of diabetes
- 15,942
Observational data: associations, not effects.
Original publication
Urinary albumin-to-creatinine ratio and incident type 2 diabetes: a 13.8-year cohort study of 411,389 UK biobank participants. Diabetes Res Clin Pract. Published 16 April 2026. doi:10.
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